abstract：:The migration of dendritic cells (DCs) from the site of antigen-encounter to regional lymphoid organs is crucial for DCs to function as potent antigen-presenting cells. Matrix metalloproteinase-9 (MMP-9) is critically for DCs migration across extracellular matrix (ECM). We verified in previous studies that hypoxia dim...

journal_title：Molecular immunology

authors： Zhao P,Li XG,Yang M,Shao Q,Wang D,Liu S,Song H,Song B,Zhang Y,Qu X

更新日期：2008-04-01 00:00:00

abstract：:The C-terminal domain of protein 4.1G was identified to interact with the cytosolic tail of the high affinity IgG receptor, Fc gamma RI, in yeast two-hybrid screens. Proteins of the 4.1 family have previously been found to mediate receptor/cytoskeleton interactions. In the study presented here, we show an alternativel...

journal_title：Molecular immunology

authors： Beekman JM,Bakema JE,van der Poel CE,van der Linden JA,van de Winkel JG,Leusen JH

更新日期：2008-04-01 00:00:00

abstract：:We previously demonstrated that some fish have unique response in the form of reactive oxygen species (ROS) production. In the present study, we cloned and sequenced the full-length cDNAs for carp (Cyprinus carpio) phagocyte NADPH oxidase components: gp91phox, p22phox, p47phox, p67phox and p40phox. These amino acid se...

journal_title：Molecular immunology

authors： Mayumi M,Takeda Y,Hoshiko M,Serada K,Murata M,Moritomo T,Takizawa F,Kobayashi I,Araki K,Nakanishi T,Sumimoto H

更新日期：2008-03-01 00:00:00

abstract：:T-cell activation requires interaction of T-cell receptors (TCR) with peptide epitopes bound by major histocompatibility complex (MHC) proteins. This interaction occurs at a special cell-cell junction known as the immune or immunological synapse. Fluorescence microscopy has shown that the interplay among one agonist p...

journal_title：Molecular immunology

authors： Wan S,Flower DR,Coveney PV

更新日期：2008-03-01 00:00:00

abstract：:Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections. Although the impaired immune status of the host is clearly the most important factor leading to disease, virulence factors of the fungus also play a role. Factor H ...

journal_title：Molecular immunology

authors： Vogl G,Lesiak I,Jensen DB,Perkhofer S,Eck R,Speth C,Lass-Flörl C,Zipfel PF,Blom AM,Dierich MP,Würzner R

更新日期：2008-03-01 00:00:00

abstract：:NKG2D receptor-ligand interaction triggers NK cell-mediated cytolysis and IFN-gamma secretion. IFN-gamma produced by NK cells has been found to promote the interaction between NK cells and monocytes; however, the underlying mechanism remains elusive. We demonstrate here that IFN-gamma exclusively induced or upregulate...

journal_title：Molecular immunology

authors： Wang H,Ruan Z,Wang Y,Han J,Fu X,Zhao T,Yang D,Xu W,Yang Z,Wang L,Chen Y,Wu Y

更新日期：2008-03-01 00:00:00

abstract：:In this study we constructed two phage libraries displaying non-immunized natural human IgM derived HCDR3 repertoires. One library was structurally constrained by a Gly to Cys substitution at position 104 enabling the formation of a disulfide bridge with the Cys at position 92. Panning of these libraries on an anti-hu...

journal_title：Molecular immunology

authors： Deroo S,Fischer A,Beaupain N,Counson M,Boutonnet N,Pletinckx J,Loverix S,Beirnaert E,De Haard H,Schmit JC,Lasters I

更新日期：2008-03-01 00:00:00

abstract：:Mycobacterium tuberculosis (M.tb) infects 8 million and kills 2.2 million people each year worldwide. M.tb modulates the immune response of the infected individual. Empirically, suppressor carbohydrates (SC) produced by CD8+ T cells in response to M.tb were found to induce a T helper 2 response rather than a protectiv...

journal_title：Molecular immunology

authors： Smit van Dixhoorn MG,Munir R,Sussman G,Stad R,de Haan M,van der Hoeven T,Rauwerda H,Breit TM,Thallinger GG,Wadee AA

更新日期：2008-03-01 00:00:00

abstract：:Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) is an immunoglobulin (Ig)-immunoreceptor tyrosine based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, predominantly SHP-2 and to a lesser extent, SHP-1. Previously, we have shown that deletion of PEC...

journal_title：Molecular immunology

authors： Wong MX,Hayball JD,Jackson DE

更新日期：2008-03-01 00:00:00

abstract：:The RING finger type E3 ubiquitin ligase, Cbl-b, is abundantly expressed in bone marrow-derived mast cells (BMMCs) and functions as a potent negative regulator of signalling responses from the high-affinity IgE receptor (FcvarepsilonRI). To determine the contribution of Cbl-b E3 ligase activity we generated knockin mi...

journal_title：Molecular immunology

authors： Oksvold MP,Dagger SA,Thien CB,Langdon WY

更新日期：2008-02-01 00:00:00

abstract：:The complement system is important for protection from invading pathogens, removal of waste products and guidance of the immune response. Furthermore, complement can be also targeted to cancer cells. However, membrane-bound inhibitors over-expressed by certain types of tumor cells restrict the cytotoxic activity of co...

journal_title：Molecular immunology

authors： Okroj M,Hsu YF,Ajona D,Pio R,Blom AM

更新日期：2008-01-01 00:00:00

abstract：:Toll-like receptors (TLR) are expressed on the surface or intracellularly by dendritic cells (DC) and recognize specifically different pathogen-associated molecular patterns (PAMPs). Increasing evidence suggests that TLR expressed by DC can cooperate to synergize their functions. Here, we describe the cooperation of T...

journal_title：Molecular immunology

authors： Theiner G,Rössner S,Dalpke A,Bode K,Berger T,Gessner A,Lutz MB

更新日期：2008-01-01 00:00:00

abstract：:In a recent article published in Molecular Immunology [Furukawa, K., Shimizu, T., Murakami, A., Kono, R., Nakagawa, M., Sagawa, T., Yamato, I., Azuma, T., 2007. Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten. Mol. Immunol. 44, 2436-2445], the authors m...

journal_title：Molecular immunology

authors： Kang J,Warren AS

更新日期：2008-01-01 00:00:00

abstract：:A first report of an XLA patient with a polymorphism in Btk SH3 domain has been identified after sequencing of the entire gene. SH3 domain variants might not be detected due to well characterized mutations outside the domain. ...

journal_title：Molecular immunology

authors： Pérez de Diego R,Bravo J,Allende LM,López-Granados E,Rivera J,Ferreira A,Fontán G,García Rodríguez MC

更新日期：2008-01-01 00:00:00

abstract：:Cationic antimicrobial peptides play important roles in host defense, linking innate and adaptive immunity. hCAP18, the only human antimicrobial cathelicidin, consists of a conserved N-terminal cathelin-like domain and a C-terminal peptide, LL-37. Expression is regulated during myeloid differentiation, and tightly con...

journal_title：Molecular immunology

authors： Elloumi HZ,Holland SM

更新日期：2008-01-01 00:00:00

abstract：:Using a combinatorial chemistry approach, we identified a tetrameric tripeptide, denoted Protein A Mimetic (PAM) or TG19318, able to bind to immunoglobulins of different classes and species. The inverso variant, with the tripeptide in the all-D configuration (D-PAM or TG19320), is described as retaining binding proper...

journal_title：Molecular immunology

authors： Rossi M,Ruvo M,Marasco D,Colombo M,Cassani G,Verdoliva A

更新日期：2008-01-01 00:00:00

abstract：:V(D)J recombination is a mechanism peculiar to the somatic rearrangement of antigen receptor genes. It requires both expression of the RAG-1 and RAG-2 recombinases and accessibility of the substrate to its recombinase and post-cleavage/DNA repair stage. TCR revision is a genetic correction mechanism that changes T cel...

journal_title：Molecular immunology

authors： Lantelme E,Orlando L,Porcedda P,Turinetto V,De Marchi M,Amoroso A,Mantovani S,Giachino C

更新日期：2008-01-01 00:00:00

abstract：:Subunits of the mitochondrial ATP synthase complex are expressed on the surface of tumors, bind the TCR of human Vgamma9/Vdelta2 lymphocytes and promote their cytotoxicity. Present experiments show that detection of the complex (called ecto-F1-ATPase) at the cell surface by immunofluorescence correlates with low MHC-c...

journal_title：Molecular immunology

authors： Vantourout P,Martinez LO,Fabre A,Collet X,Champagne E

更新日期：2008-01-01 00:00:00

abstract：:Chagas' disease, caused by Trypanosoma cruzi, is an inflammatory disorder leading to chronic Chagas cardiomyopathy (CCC). Only one third of T. cruzi-infected individuals progress to CCC while the others are considered asymptomatic (ASY). The human inhibitory kappaB-like gene (IKBL/NFKBIL1), homologous to the IkappaB f...

journal_title：Molecular immunology

authors： Ramasawmy R,Faé KC,Cunha-Neto E,Borba SC,Ianni B,Mady C,Goldberg AC,Kalil J

更新日期：2008-01-01 00:00:00

abstract：:CD20 is a cell-surface marker expressed on mature B cells and most malignant B cells, but not stem or plasma cells. It is an ideal target for monoclonal antibodies (mAb), such as rituximab and ofatumumab, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the p...

journal_title：Molecular immunology

authors： Glennie MJ,French RR,Cragg MS,Taylor RP

更新日期：2007-09-01 00:00:00

abstract：:Surfactant protein D (SP-D) interacts with various different microorganisms and plays an important role in pulmonary innate immunity. SP-D expression has also been detected in extrapulmonary tissues, including the gastro-intestinal tract. However, its function in the intestine is unknown and may differ considerably fr...

journal_title：Molecular immunology

authors： Hogenkamp A,Herías MV,Tooten PC,Veldhuizen EJ,Haagsman HP

更新日期：2007-07-01 00:00:00

abstract：:The common variant in the human complement Factor H gene (CFH), with Tyr402His, is linked to age-related macular degeneration (AMD), a prevalent disorder leading to visual impairment and irreversible blindness in elderly patients. Here we show that the risk variant CFH 402His displays reduced binding to C reactive pro...

journal_title：Molecular immunology

authors： Skerka C,Lauer N,Weinberger AA,Keilhauer CN,Sühnel J,Smith R,Schlötzer-Schrehardt U,Fritsche L,Heinen S,Hartmann A,Weber BH,Zipfel PF

更新日期：2007-07-01 00:00:00

abstract：:Mugwort (Artemisia vulgaris) belongs to the Compositae family, and is one of the main causes of allergy in late summer and autumn. The aim of the study was to characterize the allergen Art v 2 from mugwort pollen. Skin prick tests, performed in 19 patients allergic to mugwort and 10 control patients, showed an Art v 2...

journal_title：Molecular immunology

authors： Arilla MC,Ibarrola I,Puente Y,Daza JC,Martínez A,Asturias JA

更新日期：2007-07-01 00:00:00

abstract：:The sphingosine-1-phosphate analogue FTY720 is known to alter migration and homing of lymphocytes via sphingosine-1-phosphate receptors. However, several studies indicate that its mode of action is more complex and that FTY720 may also directly influence cytokine effector functions. Therefore, we studied the effect of...

journal_title：Molecular immunology

authors： Daniel C,Sartory NA,Zahn N,Schmidt R,Geisslinger G,Radeke HH,Stein JM

更新日期：2007-07-01 00:00:00

abstract：:In addition to classic Smad signaling pathways, the pleiotropic immunoregulatory cytokine TGF-beta1 can activate MAP kinases, but a role for TGF-beta1-MAP kinase pathways in T cells has not been defined heretofore. We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting IFN-gamma's induction of ...

journal_title：Molecular immunology

authors： Park IK,Letterio JJ,Gorham JD

更新日期：2007-07-01 00:00:00

abstract：:Glucocorticoids down regulate the inducible nitric oxide synthase (iNOS) gene both transcriptionally and post-transcriptionally. The post-transcriptional events are suggested to involve destabilization of the iNOS transcript although the molecular mechanisms for this effect are not known. Recently, our laboratory demo...

journal_title：Molecular immunology

authors： Söderberg M,Raffalli-Mathieu F,Lang MA

更新日期：2007-05-01 00:00:00

abstract：:Linear IgE-binding epitopes identified in legumin allergens of peanut (Ara h 3) and other allergenic tree nuts (Jug r 4 of walnut, Cor a 9 of hazelnut, Ana o 2 cashew nut) were mapped on three-dimensional models of the proteins built up by homology modelling. A conformational analysis revealed that consensual surface-...

journal_title：Molecular immunology

authors： Barre A,Jacquet G,Sordet C,Culerrier R,Rougé P

更新日期：2007-05-01 00:00:00

abstract：:Complement per se has been shown to play an important role in demyelinating disease but controversy remains regarding the role of C3 in the development and progression of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. In this study, we used C3(-/-) mice to confirm previous fi...

journal_title：Molecular immunology

authors： Szalai AJ,Hu X,Adams JE,Barnum SR

更新日期：2007-05-01 00:00:00

abstract：:Because of its lethal effects, ease of preparation, and ability to be delivered by aerosolization, ricin has been developed as a lethal weapon by various terrorist groups. When introduced into the pulmonary system of rodents, ricin causes pathological changes in the lung that are known to occur in acute respiratory di...

journal_title：Molecular immunology

authors： Korcheva V,Wong J,Lindauer M,Jacoby DB,Iordanov MS,Magun B

更新日期：2007-04-01 00:00:00

abstract：:The mis-regulation of nuclear factor-kappa B (NF-kappaB) signal pathway is involved in a variety of inflammatory diseases that leds to the production of inflammatory mediators. Our studies using human U937 promonocytes cells suggested that magnolol, a low molecular weight lignan isolated from the medicinal plant Magno...

journal_title：Molecular immunology

authors： Tse AK,Wan CK,Zhu GY,Shen XL,Cheung HY,Yang M,Fong WF

更新日期：2007-04-01 00:00:00

abstract：:We have previously identified four linear IgE epitopes on Jun a 1, the dominant allergen in mountain cedar pollen, and mapped these to the surfaces of a molecular model and to the crystal structure of this glycoprotein. The aim of the present study was to determine if Jun a 1 also displays conformational IgE epitopes....

journal_title：Molecular immunology

authors： Varshney S,Goldblum RM,Kearney C,Watanabe M,Midoro-Horiuti T

更新日期：2007-04-01 00:00:00

abstract：:The MHC class II transactivator (CIITA) acts in the cell nucleus as the master regulator of MHC class II (MHC II) gene expression. It is important to study CIITA regulation in multiple myeloma since MHC expression is central to ability of myeloma cells to present antigen and to the ability of the immune system to reco...

journal_title：Molecular immunology

authors： Zhao M,Flynt FL,Hong M,Chen H,Gilbert CA,Briley NT,Bolick SC,Wright KL,Piskurich JF

更新日期：2007-04-01 00:00:00

abstract：:The protective antigen (PA(83)) of Bacillus anthracis is the dominant antigen in natural and vaccine-induced immunity to anthrax infection. Three human single-chain variable fragments (scFvs) against cell bound PA were isolated from an antibody phage display library. Specifically, the antibodies were evaluated for the...

journal_title：Molecular immunology

authors： Steiniger SC,Altobell LJ 3rd,Zhou B,Janda KD

更新日期：2007-04-01 00:00:00

abstract：:CD55 is a key regulator of complement activation, expressed on most tissues and cells in man and other mammals. In the rat, alternative splicing in the gene encoding CD55 yields GPI-anchored (GPI-CD55) and transmembrane (TM-CD55) forms. Published Northern blot analysis indicated that while GPI-CD55 was broadly express...

journal_title：Molecular immunology

authors： Mizuno M,Donev RM,Harris CL,Morgan BP

更新日期：2007-03-01 00:00:00

abstract：:Invasive Salmonella has been reported to induce apoptosis of macrophages as a part of its infection process, which may allow it to avoid detection by the innate immune system. However, the bacterial components capable of inducing apoptosis, particularly under the environments offered by the host have not been fully id...

journal_title：Molecular immunology

authors： Chanana V,Majumdar S,Rishi P

更新日期：2007-03-01 00:00:00

abstract：:Here we present the gene structure and expression data on two Atlantic salmon TNF-alpha genes. Both genes are approximately 2.0kb in length and organized into four exons and three introns. The open reading frame of both genes translates into 246 amino acid putative peptides, being 91.5% identical at the amino acid lev...

journal_title：Molecular immunology

authors： Haugland O,Mercy IS,Romøren K,Torgersen J,Evensen O

更新日期：2007-03-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, challenges host defense mechanism by impairing the signal transduction of T cells which leads to downregulation of T cell proliferation, mainly as a consequence of interference with IL-2 production. In this study we sought to identify how soluble forms of M. leprae...

journal_title：Molecular immunology

authors： Chattree V,Khanna N,Rao DN

更新日期：2007-03-01 00:00:00

abstract：:Scygonadin is a novel antimicrobial peptide, which was originally isolated from the seminal plasma of the mud crab, Scylla serrata. Based on the partial 20-residue NH(2)-terminal sequence of the peptide, H-Gly-Gln-Ala-Leu-Asn-Lys-Leu-Met-Pro-Lys-Ile-Val-Ser-Ala-Ile-Ile-Tyr-Met-Val-Gly-OH, scygonadin was cloned from th...

journal_title：Molecular immunology

authors： Wang KJ,Huang WS,Yang M,Chen HY,Bo J,Li SJ,Wang GZ

更新日期：2007-03-01 00:00:00

abstract：:Genetic and functional studies suggest that polymorphism in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and inducible costimulator (ICOS) genes, both reported to harbour autoimmune susceptibility loci, could regulate the immune activation through affecting their expression and splicing of CTLA4. To address thi...

journal_title：Molecular immunology

authors： Kaartinen T,Lappalainen J,Haimila K,Autero M,Partanen J

更新日期：2007-03-01 00:00:00

abstract：:Reduced expression of Erythrocyte Complement Receptor 1 (E-CR1) is envisaged to contribute significantly to the pathophysiology of systemic lupus erythematosus (SLE). We determined the levels of CR1 transcript in the neutrophils from 25 untreated patients with active SLE and 25 normal healthy individuals and, studied ...

journal_title：Molecular immunology

authors： Arora V,Mondal AM,Grover R,Kumar A,Chattopadhyay P,Das N

更新日期：2007-03-01 00:00:00